| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0246 | Name | BOK-AS1 | Aliases | BOK-AS; BOKAS; NAToB; NCRNA00151 | |
| Species | Homo sapiens | Chromosome | 2 | Start site | 241544403 | |
| End site | 241558977 | Chain | minus | Exon NO. | 2 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_033346 | |
| Ensembl | ENSG00000234235 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| cancer | N/A | N/A | N/A | expression | The expression of BOKAS was found in testis and certain cancer tissues but not in other normal adult tissues. Overexpression of BOKAS was able to inhibit Bok-induced apoptosis in HeLa cells. | 24757675 | LncRNADisease | ||
| testicular cancer | qPCR etc. | cell line (Hela) | up-regulated | expression | A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. The mRNA expression of BOKAS was only detected in testis and certain cancer tissues but not in other normal adult tissues examined. | 19287972 | LncRNADisease Lnc2Cancer | ||
| esophageal squamous cell carcinoma | qPCR, Western blot, RIP etc. | ESCC tissue | up-regulated | interaction | LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance.WISP1 facilitated its own expression in response to radiation, creating a positive feedback loop and increased radioresistance. Our study revealed WISP1 as a potential target to overcome radioresistance in ESCC. | 25749038 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| WISP1 | RNA-DNA | regulation | LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance. | 25749038 | |||||