LncRNA Information
ID	EL0016	Name	AB073614	Aliases	N/A
Species	Homo sapiens	Chromosome	3	Start site	148891375
End site	148893279	Chain	N/A	Exon NO.	N/A
Assembly	N/A	Class	N/A	NCBI accession	N/A
Ensembl	N/A	Sequence	N/A

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
ovarian cancer	microarray, qPCR, Western blot, knockdown, FCA etc.	ovarain cancer tissue, cell lines (A2780, Caov3, HO-8910, OVCAR3, SKOV3 etc.)	up-regulated	interaction	Results showed that AB073614 expression was significantly up-regulated in 85.3% (64/75) cancerous tissues compared with normal counterparts. Knockdown of AB073614 expression significantly inhibited cell proliferation and invasion, resulted in cell arrest in G1 phase of cell cycle and a dramatic increase of apoptosis. Finally, western blot assays indicated that lncRNA AB073614 may exert its function by targeting ERK1/2 and AKT-mediated signaling pathway. In conclusion, our study suggests that lncRNA AB073614 acts as a functional oncogene in OC development.	26299803	Lnc2Cancer
glioma	qRT-PCR	N/A	up-regulated	N/A	AB073614 expression was significantly up-regulated in cancerous tissues compared with normal brain tissues	27104549

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
ERK1/2 and AKT-mediated signaling pathway	RNA-Protein	regulation	western blot assays indicated that lncRNA AB073614 may exert its function by targeting ERK1/2 and AKT-mediated signaling pathway.	26299803