LncRNA Information
ID	EL0984	Name	NONRATT021972	Aliases	N/A
Species	Rattus norvegicus	Chromosome	4	Start site	N/A
End site	N/A	Chain	N/A	Exon NO.	N/A
Assembly	N/A	Class	N/A	NCBI accession	N/A
Ensembl	N/A	Sequence	N/A

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
type 2 diabetes mellitus	N/A	Type 2 diabetes mellitus (T2DM) rat model, T2DM patient serum	up-regulated	interaction	MWT and TWL in T2DM rats treated with NONRATT021972 siRNA were higher compared with those in T2DM rats. NONRATT021972 siRNA treatment may suppress the upregulated expression and activation of the P2X3 receptor and reduce the hyperalgesia potentiated by the pro-inflammatory cytokine TNF-α in T2DM rats.	26742527
diabetic neuropathic pain	NONRATT021972 siRNA treatment in type 2 DM rats	diabetes mellitus (DM) group and control group	up-regulated	N/A	NONRATT021972 siRNA treatment can decrease the expression levels of P2X7 mRNA and protein and inhibit the activation of satellite glial cells (SGCs)	27107575
P2X7-mediated PC12 neuronal injury	PC12 cells under OGD conditions	PC12 cells	N/A	N/A	Treatment with NONRATT021972 siRNA reversed the decreased viability of PC12 cells under OGD conditions	27100355

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
ERK1/2	RNA-Protein	regulation	NONRATT021972 siRNA inhibited the phosphorylation and activation of ERK1/2 in T2DM DRG.	26742527
P2X3	RNA-DNA	regulation	The expression levels of the P2X3 protein and messenger RNA (mRNA) of T2DM rat DRG were higher compared to the control, while those in T2DM rats treated with NONRATT021972 siRNA were significantly lower compared to T2DM rats.	26742527
TNF-α	RNA-Protein	regulation	The level of tumor necrosis factor-α (TNF-α) in the serum of T2DM rats treated with NONRATT021972 siRNA was significantly decreased compared with T2DM rats.	26742527