| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0969 | Name | NCRUPAR | Aliases | NCRNA00193; ncR-uPAR | |
| Species | Homo sapiens | Chromosome | 5 | Start site | 76712403 | |
| End site | 76712888 | Chain | plus | Exon NO. | 1 | |
| Assembly | GRCh38.p7 | Class | N/A | NCBI accession | NR_028375 | |
| Ensembl | N/A | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| gastric cancer | qPCR etc. | gastric cancer tissue | down-regulated | N/A | The level of ncRuPAR in gastric cancer was low, and its expression level was associated with invasion depth, lymph node metastasis, distant metastasis, tumor size, and TNM stage. These findings indicate that ncRuPAR might be a potential marker for gastric cancer diagnosis. ncRuPAR might also be a tumor suppressor because it regulates the expression of PAR-1. | 24817013 | Lnc2Cancer | ||
| colorectal cancer | qPCR, Immunohistochemistry etc. | CRC tissue | down-regulated | interaction | Our results indicated that the expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. The expression of ncRuPAR was significantly correlated with lymph node metastasis, distant metastasis, Duck's stage, differentiation, and TNM stage and was potentially negatively associated with the mRNA levels and EI scores of PAR-1. | 25119598 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| PAR-1 | RNA-DNA | regulation | The ncR-uPAR upregulated PAR-1-core promoter-driven luciferase activity and mRNA expression in vitro in a Pol II-dependent manner. This noncoding RNA appears to act in trans, albeit locally at the adjacent PAR-1 promoter. | 12084570 | LncRNADisease | ||||
| PAR-1 | RNA-Protein | regulation | The expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. | 25119598 | |||||