| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0959 | Name | NALT1 | Aliases | LINC01573; MIR4674HG; NALT | |
| Species | Homo sapiens | Chromosome | 9 | Start site | 136546212 | |
| End site | 136549893 | Chain | plus | Exon NO. | 3 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_121577 | |
| Ensembl | ENSG00000237886 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| pediatric T cell acute lymphoblastic leukemia | CCK8 assay and EDU stain, western blot | pediatric T cell acute lymphoblastic leukemia cells | N/A | interaction | Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain. Gal4-λN/BoxB reporter system revealed that the nuclear located NALT could function as a transcription activator which caused an activation of NOTCH signal pathway as confirmed by western blot. | 26330272 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| NOTCH1 | RNA-Protein | regulation | Up-regulation of NALT associating with NOTCH1 in human samples. A neighbor of NOTCH1, Lnc-RP11-611D20.2 (named NALT) which could regulate the NOTCH1 signal pathway through cis-regulation. | 26330272 | |||||