LncRNA Information
ID	EL0884	Name	Mira	Aliases	Mira
Species	Mus musculus	Chromosome	6	Start site	52214491
End site	52215288	Chain	minus	Exon NO.	1
Assembly	GRCm38.p4	Class	N/A	NCBI accession	NR_045199
Ensembl	N/A	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
mixed lineage leukemia 1	N/A	mouse embryonic stem cells (mESC)	N/A	N/A	the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin.	21925392

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
Hoxa6	RNA-DNA	regulation	Here, we demonstrate that the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin.	21925392	LncRNADisease
Hoxa7	RNA-DNA	regulation	Here, we demonstrate that the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin.	21925392	LncRNADisease
MLL1	RNA-Protein	binding	Here, we demonstrate that the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin.	21925392	LncRNADisease
Hoxa6 and Hoxa7	RNA-DNA	regulation	Mira-mediated recruitment of MLL1 to the Mira gene triggers dynamic changes in chromosome onformation, culminating in activation of Hoxa6 and Hoxa7 transcription. Hoxa6 and Hoxa7 activate the expression of genes involved in germ layer specification during mESC differentiation in a cooperative and redundant fashion. Our results connect the lncRNA Mira with the recruitment of MLL1 to target genes and implicate lncRNAs in epigenetic activation of gene expression during vertebrate cell-fate determination.	21925392