LncRNA Information
ID EL0883 Name MIR99AHG Aliases C21orf34; C21orf35; LINC00478; MONC
Species Homo sapiens Chromosome 21 Start site 15928296
End site 16627397 Chain plus Exon NO. 18
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_136541, NR_136542, NR_027790, NR_111005, NR_111004, NR_136552, NR_136551, NR_027791, NR_136543, N
Ensembl ENSG00000215386 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
acute megakaryoblastic leukemia qPCR etc. blood, cell lines (CMK, Meg-01, K562, HT1080 and 293 T etc.) up-regulated N/A Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding miRNA clusters. Knockdown of MONC or MIR100HG impeded leukemic growth of AMKL cell lines and primary patient samples. Our study reveals an unprecedented function of lncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. 25027842 Lnc2Cancer