LncRNA Information
ID EL0874 Name MIR100HG Aliases AGD1; linc-NeD125; lncRNA-N2
Species Homo sapiens Chromosome 11 Start site 122028327
End site 122556721 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_024430
Ensembl ENSG00000255248 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
myopia N/A N/A N/A locus LOC399959 was identified within a 200-kb DNA encompassing rs577948. 19779542 LncRNADisease
acute megakaryoblastic leukemia qPCR etc. blood, cell lines (CMK, Meg-01, K562, HT1080 and 293 T etc.) up-regulated N/A Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding miRNA clusters. Knockdown of MONC or MIR100HG impeded leukemic growth of AMKL cell lines and primary patient samples. Our study reveals an unprecedented function of lncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. 25027842 Lnc2Cancer