LncRNA Information
ID EL0873 Name MINCR Aliases LINC01604
Species Homo sapiens Chromosome 8 Start site 143280161
End site 143281690 Chain minus Exon NO. 3
Assembly Ensembl Release 89 Class antisense NCBI accession NR_120682, NR_120683
Ensembl ENSG00000253716 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Burkitt's lymphoma knockdown two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas with or without genetic variants resulting in MYC overexpression N/A interaction MINCR knockdown is associated with an impairment in cell cycle progression. Differential gene expression analysis after RNAi showed a significant enrichment of cell cycle genes among the genes down-regulated after MINCR knockdown. Down-regulation of Aurora kinases A and B and chromatin licensing and DNA replication factor 1 may explain the reduction in cellular proliferation observed on MINCR knockdown. 26351698

Interaction target Level of interaction Type of interaction Description PMID Source
MYC RNA-DNA regulation MINCR acts as a modulator of the MYC transcriptional program. MINCR knockdown was associated with a reduction in MYC binding to the promoters of selected cell cycle genes. 26351698