LncRNA Information
ID EL0868 Name Mhrt Aliases D830015G02Rik; ENSMUSG00000053118; Myheart
Species Mus musculus Chromosome 14 Start site 54968678
End site 54974349 Chain plus Exon NO. 5
Assembly Ensembl Release 89 Class antisense NCBI accession NR_033497
Ensembl ENSMUSG00000097652 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
heart hypertrophy Northern blot and in situ Hybridization,ChIP–qPCR N/A N/A interaction Pathological stress activates the Brg1-Hdac-Parp chromatin repressor complex to inhibit Mhrt transcription in the heart. Such stress-induced Mhrt repression is essential for cardiomyopathy to develop. 25119045

Interaction target Level of interaction Type of interaction Description PMID Source
Brg1 RNA-Protein binding Mhrt prevents Brg1 from recognizing its genomic DNA targets, thus inhibiting chromatin targeting and gene regulation by Brg1. It does so by binding to the helicase domain of Brg1, a domain that is crucial for tethering Brg1 to chromatinized DNA targets. 25119045