| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0868 | Name | Mhrt | Aliases | D830015G02Rik; ENSMUSG00000053118; Myheart | |
| Species | Mus musculus | Chromosome | 14 | Start site | 54968678 | |
| End site | 54974349 | Chain | plus | Exon NO. | 5 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_033497 | |
| Ensembl | ENSMUSG00000097652 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| heart hypertrophy | Northern blot and in situ Hybridization,ChIP–qPCR | N/A | N/A | interaction | Pathological stress activates the Brg1-Hdac-Parp chromatin repressor complex to inhibit Mhrt transcription in the heart. Such stress-induced Mhrt repression is essential for cardiomyopathy to develop. | 25119045 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| Brg1 | RNA-Protein | binding | Mhrt prevents Brg1 from recognizing its genomic DNA targets, thus inhibiting chromatin targeting and gene regulation by Brg1. It does so by binding to the helicase domain of Brg1, a domain that is crucial for tethering Brg1 to chromatinized DNA targets. | 25119045 | |||||