LncRNA Information
ID EL0862 Name Meg3 Aliases 2900016C05Rik; 3110050O07Rik; 6330408G06Rik; AI425946; AW108224; D12Bwg1266e; Gtl2; R74756; R75394
Species Mus musculus Chromosome 12 Start site 109541001
End site 109571726 Chain plus Exon NO. 11
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_027652, NR_027651, NR_003633
Ensembl ENSMUSG00000021268 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
diabetes mellitus MEG3 knockdown STZ-induced diabetic mice N/A N/A knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro 26845358
non-functioning pituitary adenoma Quantitative RT-PCR immunohistological Meg3 knockout mice up-regulated expression Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis 20392836

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
compared between freshly-isolated and cultured dental mesenchymal cells mouse dental mesenchymal cells down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue N/A loss of odontogenic potential 26986487
Northern blot hybridizations N/A N/A expression None of the atg codons of these orfs is in the context of a strong kozak consensus sequence for initiation of translation, suggesting that gtl2 might function as an rna. primary gtl2 transcripts are differently processed in various cell types during development. 9626496