LncRNA Information
ID EL0854 Name Malat1 Aliases 2210401K01Rik; 9430072K23Rik; AI647968; Neat2
Species Mus musculus Chromosome 19 Start site 5795690
End site 5802672 Chain minus Exon NO. 1
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_002847
Ensembl ENSMUSG00000092341 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hereditary degenerative disease myotonic dystrophy type 1 knockdown a transgenic mouse model of DM1 N/A expression Systemically administered ASOs were also effective for muscle knockdown of Malat1, a long non-coding RNA (lncRNA) that is retained in the nucleus. 22859208
mammary carcinoma knockdown MMTV (mouse mammary tumor virus)-PyMT mouse mammary carcinoma model N/A expression Malat1 loss results in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-amplified tumor organoids, increased cell adhesion, and loss of migration. 26701265
Flavivirus infection N/A N/A N/A expression Activation of Malat1 following infection by two flaviviruses, both of which activate the UPR in host cells. 26634309

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
compared between freshly-isolated and cultured dental mesenchymal cells mouse dental mesenchymal cells down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue N/A loss of odontogenic potential 26986487
knock-down, DNA microarray analysis hippocampal neurons Up-regulated regulation modulates the recruitment of SR family pre-mRNA-splicing factors 20729808
Northern blot,knockdown,RNA-seq a Malat1 loss-of-function genetic model N/A interaction Malat1 is not essential for mouse pre- and postnatal development. However, among a small number of genes that were dysregulated in adult Malat1 knockout mice, many were Malat1 neighboring genes, thus indicating a potential cis-regulatory role of Malat1 gene transcription. a potential cis-regulatory role of Malat1 gene transcription. 22840402