| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0854 | Name | Malat1 | Aliases | 2210401K01Rik; 9430072K23Rik; AI647968; Neat2 | |
| Species | Mus musculus | Chromosome | 19 | Start site | 5795690 | |
| End site | 5802672 | Chain | minus | Exon NO. | 1 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_002847 | |
| Ensembl | ENSMUSG00000092341 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| hereditary degenerative disease myotonic dystrophy type 1 | knockdown | a transgenic mouse model of DM1 | N/A | expression | Systemically administered ASOs were also effective for muscle knockdown of Malat1, a long non-coding RNA (lncRNA) that is retained in the nucleus. | 22859208 | |||
| mammary carcinoma | knockdown | MMTV (mouse mammary tumor virus)-PyMT mouse mammary carcinoma model | N/A | expression | Malat1 loss results in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-amplified tumor organoids, increased cell adhesion, and loss of migration. | 26701265 | |||
| Flavivirus infection | N/A | N/A | N/A | expression | Activation of Malat1 following infection by two flaviviruses, both of which activate the UPR in host cells. | 26634309 | |||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| compared between freshly-isolated and cultured dental mesenchymal cells | mouse dental mesenchymal cells | down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue | N/A | loss of odontogenic potential | 26986487 | ||||
| knock-down, DNA microarray analysis | hippocampal neurons | Up-regulated | regulation | modulates the recruitment of SR family pre-mRNA-splicing factors | 20729808 | ||||
| Northern blot,knockdown,RNA-seq | a Malat1 loss-of-function genetic model | N/A | interaction | Malat1 is not essential for mouse pre- and postnatal development. However, among a small number of genes that were dysregulated in adult Malat1 knockout mice, many were Malat1 neighboring genes, thus indicating a potential cis-regulatory role of Malat1 gene transcription. a potential cis-regulatory role of Malat1 gene transcription. | 22840402 | ||||