LncRNA Information
ID EL0843 Name LSINCT5 Aliases N/A
Species Homo sapiens Chromosome 5 Start site 2712591
End site 2715237 Chain plus Exon NO. N/A
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_145480
Ensembl ENSG00000281560 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer N/A N/A N/A expression Ovarian and breast tumours have also been associated with the expression of the LSINCT5 lncRNA; this transcript acts to target several other transcripts, including the antisense RNA NEAT-1 and the PSPC1 gene, which codes for a splicing regulatory factor 22817756 LncRNADisease
ovarian cancer N/A N/A N/A expression Ovarian and breast tumours have also been associated with the expression of the LSINCT5 lncRNA; this transcript acts to target several other transcripts, including the antisense RNA NEAT-1 and the PSPC1 gene, which codes for a splicing regulatory factor 22817756 LncRNADisease
gastric cancer qPCR etc. gastric cancer tissue, cell lines (AGS, MKN-45, MGC-803, BGC-823, HGC-27) up-regulated N/A The expression of LSINCT5 is significantly upregulated in gastrointestinal cancer tissues and cell lines relative to their normal counterparts. In addition, increased LSINCT5 expression was correlated with a larger tumor size, deeper tumor depth, and advanced clinical stage. 25526476 LncRNADisease Lnc2Cancer
colorectal cancer qPCR etc. CRC tissue, cell lines (LoVo, Caco-2, DLD1,HCT-8, HCT-116) up-regulated N/A The expression of LSINCT5 is significantly upregulated in gastrointestinal cancer tissues and cell lines relative to their normal counterparts. Increased LSINCT5 expression was correlated with a larger tumor size, deeper tumor depth, and advanced clinical stage. Gastric cancer (GC) and colorectal cancer (CRC) patients with higher LSINCT5 expression levels have worse disease-free survival (DFS) and disease-specific survival (DSS) rates. 25526476 LncRNADisease Lnc2Cancer
gastric cancer qPCR etc. cancerous gastric tissue, blood (serum) up-regulated expression A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. 25694351 Lnc2Cancer
breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
breast cancer qPCR, Northern blot, etc. cell lines (HMEC, MCF7, MDA157 etc.) up-regulated expression LSINCT5 is overexpressed in breast and ovarian cancer cell lines and tumor tissues. 21532345 LncRNADisease Lnc2Cancer
ovarian cancer qPCR, Northern blot, etc. cell lines (OVCAR5, NHBE etc.) up-regulated expression LSINCT5 is overexpressed in breast and ovarian cancer cell lines and tumor tissues. 21532345 LncRNADisease Lnc2Cancer
breast cancer qPCR, Northern blot, knock-down, Microarray human bronchial epithelial (NHBE) cells, breast cancer cell line, ovarian cancer cell line up-regulated expression knock-down of LSINCT5 expression decreased proliferation in human breast and ovarian cancer cells; Using a genome tiling array to identify noncoding sequences upregulated in normal human bronchial epithelial (NHBE) cells exposed to a DNA-damaging tobacco carcinogen 26323562
ovarian cancer qPCR, Northern blot, knock-down, Microarray human bronchial epithelial (NHBE) cells, breast cancer cell line, ovarian cancer cell line up-regulated expression knock-down of LSINCT5 expression decreased proliferation in human breast and ovarian cancer cells; Using a genome tiling array to identify noncoding sequences upregulated in normal human bronchial epithelial (NHBE) cells exposed to a DNA-damaging tobacco carcinogen 26323562
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
PSPC1 RNA-RNA co-expression Two genes that were significantly downregulated were the lncRNA NEAT-1 and a protein coding gene PSPC1. 21532345 LncRNADisease