LncRNA Information
ID EL0829 Name AC100861.1 Aliases RP11-1149O23.3
Species Homo sapiens Chromosome 8 Start site 23224471
End site 23230926 Chain plus Exon NO. 3
Assembly Ensembl Release 89 Class antisense NCBI accession NR_033928
Ensembl ENSG00000246582 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
pancreatic ductal adenocarcinoma knockdown, overexpression pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines up-regulated interaction Knockdown of LOC389641 impaired cell proliferation and invasion and induced cell apoptosis in vitro, whereas overexpression of LOC389641 had the opposite effect. LOC389641 promotes PDAC progression and increases cell invasion by regulating E-cadherin with the possible involvement of TNFRSF10A. 26708505

Interaction target Level of interaction Type of interaction Description PMID Source
E-cadherin RNA-Protein co-expression A significant negative correlation was observed between E-cadherin levels and LOC389641 levels in vivo. Knockdown of LOC389641 upregulated E-cadherin expression, but knockdown of E-cadherin had a limited influence on LOC389641. Importantly, after E-cadherin was inhibited, the enhancement of LOC389641 on cell invasion was hindered. 26708505
TNFRSF10A DNA-DNA regulation The expression of LOC389641 was closely associated with its genomic neighboring gene TNFRSF10A. Lastly, knockdown experiments showed that TNFRSF10A might be a connection between LOC389641and E-cadherin. 26708505