| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0080 | Name | APOA1-AS | Aliases | N/A | |
| Species | Homo sapiens | Chromosome | 11 | Start site | 116836117 | |
| End site | 116855729 | Chain | plus | Exon NO. | 2 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_126362 | |
| Ensembl | ENSG00000235910 | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| Chromatin immunoprecipitation (ChIP) analyses, Targeting APOA1-AS with short antisense oligonucleotides | human and monkey liver cells | down-regulated | N/A | acts as a negative transcriptional regulator of APOA1 both in vitro and in vivo. Inhibition of APOA1-AS in cultured cells resulted in the increased expression of APOA1 and two neighboring genes in the APO cluster. | 24388749 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| APOA1 | RNA-Protein | regulation | APOA1-AS can modulate distinct histone methylation patterns that mark active and/or inactive gene expression through the recruitment of histone-modifying enzymes. | 24388749 | |||||