LncRNA Information | ||||||
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ID | EL0073 | Name | Alu lncRNAs | Aliases | N/A | |
Species | Homo sapiens | Chromosome | N/A | Start site | N/A | |
End site | N/A | Chain | N/A | Exon NO. | N/A | |
Assembly | N/A | Class | N/A | NCBI accession | N/A | |
Ensembl | N/A | Sequence | N/A |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
macular degeneration | N/A | N/A | N/A | expression | Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms | 23791884 | LncRNADisease | ||
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
Biochemical assays to probe the network of protein-DNA interactions | mouse B2 RNA and human Alu RNA | N/A | interaction | We conclude that B2 and Alu RNA prevent Pol II from properly engaging the DNA during closed complex formation, resulting in complexes with an altered conformation that are transcriptionally inert. In the absence of its normal contacts with the promoter, Pol II is likely held in these inactive complexes on DNA through interactions with promoter-bound TATA box-binding protein and transcription factor IIB. | 19307572 | ||||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
Pol II | RNA-Protein | binding | B2 and Alu RNAs bind directly and tightly to Pol II and co-occupy the promoters of repressed genes along with the polymerase | 19307572 | |||||