LncRNA Information
ID EL0718 Name linc-ITGB1 Aliases linc-ITGB1
Species Homo sapiens Chromosome 10 Start site 32900319
End site 33005792 Chain minus Exon NO. 18
Assembly Ensembl Release 89 Class lincRNA NCBI accession N/A
Ensembl ENSG00000150093 Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer qPCR, Western blot, knockdown, Flow cytometry assay etc. breast cancer tissue, cell lines (MDA-MB-231, MCF-7, T47D, ZR-75-30, 1590 etc.) up-regulated interaction The expression of linc-ITGB1 was significantly upregulated in both clinical breast cancer tissues and cultured breast cancer cell lines. Linc-ITGB1 depletion caused cell accumulation in the G0/G1 phase. Furthermore, the linc-ITGB1 knockdown decreased the expression of mesenchymal markers N-cadherin and vimentin while increasing the expression of the epithelial marker E-cadherin. Key cell cycle regulators Cdc25C and Cyclin B1 were also decreased by the linc-ITGB1 knockdown. These data suggest that linc-ITGB1 promotes breast cancer progression by inducing cell-cycle arrest and interrupting the epithelial-to-mesenchymal transition (EMT) process. 26601916 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
N-cadherin, vimentin, E-cadherin, Cdc25C, Cyclin B1 RNA-Protein regulation The linc-ITGB1 knockdown decreased the expression of mesenchymal markers N-cadherin and vimentin while increasing the expression of the epithelial marker E-cadherin. Key cell cycle regulators Cdc25C and Cyclin B1 were also decreased by the linc-ITGB1 knockdown. 26601916