LncRNA Information
ID EL0657 Name LINC00467 Aliases C1orf97
Species Homo sapiens Chromosome 1 Start site 211382803
End site 211435333 Chain plus Exon NO. 6
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_026761
Ensembl ENSG00000153363 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
neuroblastoma microarray, qPCR, Luciferase reporter assay, knockdown etc. cell lines (BE(2)-C ) differential expression N/A Chromatin immunoprecipitation and luciferase assays showed that N-Myc suppressed linc00467 gene expression through direct binding to the linc00467 gene promoter and reducing linc00467 promoter activity. While N-Myc suppressed the expression of RD3, the protein-coding gene immediately down-stream of linc00467 gene, through direct binding to the RD3 gene promoter and reducing RD3 promoter activity, linc00467 reduced RD3 mRNA expression. Importantly, knocking-down linc00467 expression with siRNA in neuroblastoma cells reduced the number of viable cells and increased the percentage of apoptotic cells, and co-transfection with DKK1 siRNA blocked the effects. 24586304 Lnc2Cancer