| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0610 | Name | ILF3 | Aliases | CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b; NFAR; NFAR-1; NFAR2; TCP110; TCP80 | |
| Species | Homo sapiens | Chromosome | 19 | Start site | 10654261 | |
| End site | 10692417 | Chain | plus | Exon NO. | 23 | |
| Assembly | Ensembl Release 89 | Class | retained intron | NCBI accession | N/A | |
| Ensembl | ENSG00000129351 | Sequence | N/A | |||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| overexpression | human fibroblast cells | down-regulated | interaction | Overexpression of SALNR delayed cellular senescence in fibroblast cells. Ras-induced stress promotes NF90 nucleolus translocation and suppresses its ability to suppress senescence-associated miRNA biogenesis, which could be rescued by SALNR overexpression. | 26487301 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| NF90 (nuclear factor of activated T-cells, 90 kDa) | RNA-Protein | regulation | SALNR interacts with NF90 (nuclear factor of activated T-cells, 90 kDa), an RNA-binding protein suppressing miRNA biogenesis. NF90 is a SALNR downstream target, whose inhibition led to premature senescence and enhanced expressions of senescence-associated miRNAs. | 26487301 | |||||