LncRNA Information
ID EL0608 Name IGF2-AS Aliases IGF2-AS1; IGF2AS; PEG8
Species Homo sapiens Chromosome 11 Start site 2140501
End site 2148666 Chain plus Exon NO. 3
Assembly Ensembl Release 89 Class antisense NCBI accession NR_028043, NR_133657
Ensembl ENSG00000099869 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
type 1 diabetes mellitus N/A N/A N/A mutation Association identified by GWAS. 17554260 LncRNADisease
prostate cancer N/A N/A N/A mutation Association identified by GWAS. 19767753 LncRNADisease
Wilms' tumor qPCR, Northern blot etc. Wilms' tumor tissue up-regulated expression PEG8/IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively. 10731720 LncRNADisease Lnc2Cancer
Wilms' tumor qPCR, Northern blot etc. Wilms' tumor tissue down-regulated N/A IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues. In Wilms' tumors that demonstrate maintenance of imprinting of IGF2, IGF2-AS was imprinted. 12702581 LncRNADisease Lnc2Cancer
liver cancer qPCR, Northern blot etc. liver cancer tissue up-regulated expression Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. 12702581 LncRNADisease Lnc2Cancer
hepatocelluar carcinoma qPCR, Southern blot etc. SMMC-7721 cell line differential expression N/A IGF-IR and IGF-IIR antisense genes could significantly restrain the malignant behavior of human hepatoma cells and might be useful in investigating a potential route for hepatocellular carcinoma gene therapy. 12603530 LncRNADisease Lnc2Cancer
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
RNA-seq, qRT-PCR three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue N/A N/A Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. 25528156