LncRNA Information
ID EL0593 Name Hsromega Aliases Dmel_CR31400; CR31400; DmelCR31400; HSRomega; Hsr-omega; Hsr93D-n; er3; hrsomega; hsr omega; hsr-omega; hsromega; hsrw; l(3)05241; l(3)93De; l(3)er3; n(3)05241; Hsromega
Species Drosophila melanogaster Chromosome 3R Start site 21296127
End site 21317836 Chain plus Exon NO. 2
Assembly Release 6 plus ISO1 MT Class N/A NCBI accession NR_048444, NR_074035, NR_002068, NR_074036, NR_133429, NR_002067, NR_002069
Ensembl N/A Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
polyglutamine diseases RNA interference N/A down-regulated interaction Loss of hsromega-n RNA not only suppresses the eye-specific degeneration mediated by GMR-GAL4 driven expression of the 127Q or MJDtr-Q78 or ataxin1 82Q or httex1p Q93 transgene, but also rescues premature death of flies expressing the expanded polyQ proteins pan-neuronally using the elav-GAL4 driver. 19667761
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
Fluorescence RNA, In situ immunocytochemical staining N/A N/A interaction The hsromega-n transcripts play essential structural and functional roles in organizing and establishing the hnrnp-containing omega speckles and thus regulate the trafficking and availability of hnrnps and other related rna binding proteins in the cell nucleus. 10984439
in situ hybridization nonstressed cells N/A expression Transcripts appear abruptly at the time that the zygotic genome becomes transcriptionally active, shortly before the formation of the cellular blastoderm. 1704862
RNA in situ hybridization somatic cyst cells N/A interaction These results further support a significant role of the noncoding hsromega-n transcripts in basic cellular activities, namely regulation of the availability of hnrnps in active (chromatin bound) and inactive (in omega speckles) compartments. 11910129
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
hnRNPs RNA-Protein binding Immunoprecipitation studies using the hnrnp antibodies further demonstrated a physical association of hnrnps and hsromega transcripts. 10984439
hnRNPs RNA-Protein regulation It appears that the p transposon insertion in the promoter region causes a misregulated overexpression of hsromega in cyst cells, which in turn results in excessive sequestration of hnrnps and formation of large clusters of omega speckles in these cell nuclei. 11910129
127Q or MJDtr-Q78 or ataxin1 82Q or httex1p Q93 transgene RNA-Protein regulation Loss of hsromega-n RNA not only suppresses the eye-specific degeneration mediated by GMR-GAL4 driven expression of the 127Q or MJDtr-Q78 or ataxin1 82Q or httex1p Q93 transgene, but also rescues premature death of flies expressing the expanded polyQ proteins pan-neuronally using the elav-GAL4 driver. 19667761