LncRNA Information
ID	EL0584	Name	HOXA11-AS	Aliases	HOXA-AS51; HOXA11AS; HOXA11S; NCRNA00076; HOXA11-AS
Species	Homo sapiens	Chromosome	7	Start site	27184518
End site	27189293	Chain	plus	Exon NO.	2
Assembly	Ensembl Release 89	Class	antisense	NCBI accession	NR_002795
Ensembl	ENSG00000240990	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
ovarian cancer	qPCR, Western blot etc.	ovarian cancer tissue	down-regulated	mutation	Functional studies of ectopic expression of HOXA11-AS minor allele T in EOC cells showed decreased survival, proliferation, migration, and invasion compared to common allele A expression. Additionally, stable expression of HOXA11-AS minor allele T reduced primary tumor growth in mouse xenograft models to a greater extent than common allele A. Furthermore, HOXA11-AS expression levels were significantly lower in human EOC tumors than normal ovarian tissues (p < 0.05), suggesting that HOXA11-AS has a tumor suppressor function in EOC which may be enhanced by the T allele	26430965	Lnc2Cancer

Function (not disease relevant)
Methods	Sample/condition	Expression pattern	Dysfunction type	Description	PMID	Source
N/A	N/A	N/A	interaction	Hoxa11 antisense functions by transcriptional interference, repressing hoxa11 expression by competing for transcription of the common gene, rather than by sense/antisense interaction.	12050232
serial section and whole-mount in situ hybridizations	N/A	N/A	expression	In the developing limbs, the sense and antisense transcripts showed complementary expression patterns	7789268

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
HOXA11	RNA-DNA	regulation	Hoxa11 antisense functions by transcriptional interference, repressing hoxa11 expression by competing for transcription of the common gene, rather than by sense/antisense interaction.	12050232
Hoxa 11	RNA-RNA	co-expression	In the developing limbs, the sense and antisense transcripts showed complementary expression patterns	7789268