LncRNA Information
ID EL0555 Name H19 Aliases AI747191
Species Mus musculus Chromosome 7 Start site 142575529
End site 142578143 Chain minus Exon NO. 5
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_130974, NR_130973
Ensembl ENSMUSG00000000031 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
overgrowth transgenic embryos of mice lacking H19 down-regulated mutation Mice lacking H19 show an overgrowth phenotype, due to a cis effect of the H19 locus on the adjacent Igf2 gene. 19762426

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
deletion of the H19 transcription N/A N/A expression The homozygous mutant animals are viable and fertile and display an overgrowth phenotype of 8% compared with wild-type littermates. 9203585
genetic complementation approach H19 KO myoblast cells N/A interaction Ectopic expression of the mouse 91H RNA can up-regulate Igf2 expression in trans 22662250
knockdown, overexpression N/A N/A interaction H19 modulates let-7 availability by acting as a molecular sponge. H19 depletion causes precocious muscle differentiation, a phenotype recapitulated by let-7 overexpression. 24055342

Interaction target Level of interaction Type of interaction Description PMID Source
Igf2 of imprinted gene network (IGN) RNA-Protein regulation We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos. An extensive analysis of several other genes from the newly described imprinted gene network (IGN) was performed in both loss- and gain-of-function animals. We found that H19 deletion leads to the upregulation of several genes of the IGN. 19762426
let-7 RNA-RNA binding Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7. 25399420
Igf2 (insulin-like growth factor 2) RNA-DNA regulation This is associated with the disruption of igf2 imprinting and the consequent biallelic expression of this gene. 9203585