| Disease |
| Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| gastric cancer |
hypoxia-induced GC and normoxia conditions using microarrays |
hypoxia-induced GC cells |
up-regulated |
N/A |
lncRNA-AK123072/EGFR pathway in gastric cancer pathogenesis |
26884908 |
|
| gastric cancer |
qPCR etc. |
gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) |
up-regulated |
expression |
All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. |
26096073 |
Lnc2Cancer
|
| bladder cancer |
qPCR, Western blot, in vitro knockdown etc. |
bladder cancer tissue |
up-regulated |
expression |
In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. |
25400817 |
Lnc2Cancer
|
| gastric cancer |
qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. |
gastric cancer tissue, cell lines (MKN45, AGS etc.) |
up-regulated |
regulation |
Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. |
24397586 |
LncRNADisease Lnc2Cancer
|
| |