LncRNA Information
ID EL0519 Name GACAT2 Aliases MTCL1-AS1; MTCL1AS1
Species Homo sapiens Chromosome 18 Start site 8695856
End site 8707621 Chain minus Exon NO. 2
Assembly Ensembl Release 89 Class antisense NCBI accession NR_120598
Ensembl ENSG00000265962 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
non-small cell lung cancer qPCR etc. NSCLC tissue, cell lines (A549, H157, HEK-293T) down-regulated expression lncRNA HMlincRNA717 expression level was significantly decreased in NSCLC tissues in comparison to adjacent non-tumor tissues. It was also proved that HMlincRNA717 expression was to be associated with NSCLC histological grade, and lymph node metastasis. In addition, survival analysis proved that down-regulated HMlincRNA717 expression was associated with poor overall survival of NSCLC patients. HMlincRNA717 expression was an independent prognostic factor for patients with NSCLC, which might be a potential prognostic biomarker and therapeutic target for NSCLC. 25674259 Lnc2Cancer
gastric cancer qPCR, PIR etc. gastric cancer tissue, cell lines (AGS, BGC-823, HGC-27, MGC-803, SGC-7901 etc.) down-regulated N/A The expression levels of HMlincRNA717 in five gastric cancer cell lines, AGS, BGC-823, HGC-27, MGC-803, and SGC-7901, were significantly downregulated than those in normal gastric mucosal epithelial cell line GES-1. More importantly, our results indicated that HMlincRNA717 expression levels were correlated with cancer distal metastasis (P = 0.034), venous invasion (P = 0.029), and nervous invasion (P = 0.024). lncRNA-HMlincRNA717 may play crucial roles during cancer occurrence and progression and may be a new potential biomarker of early gastric cancer. 24961350 Lnc2Cancer