non-small cell lung cancer |
qPCR etc. |
NSCLC tissue, cell lines (A549, H157, HEK-293T) |
down-regulated |
expression |
lncRNA HMlincRNA717 expression level was significantly decreased in NSCLC tissues in comparison to adjacent non-tumor tissues. It was also proved that HMlincRNA717 expression was to be associated with NSCLC histological grade, and lymph node metastasis. In addition, survival analysis proved that down-regulated HMlincRNA717 expression was associated with poor overall survival of NSCLC patients. HMlincRNA717 expression was an independent prognostic factor for patients with NSCLC, which might be a potential prognostic biomarker and therapeutic target for NSCLC. |
25674259 |
Lnc2Cancer
|
gastric cancer |
qPCR, PIR etc. |
gastric cancer tissue, cell lines (AGS, BGC-823, HGC-27, MGC-803, SGC-7901 etc.) |
down-regulated |
N/A |
The expression levels of HMlincRNA717 in five gastric cancer cell lines, AGS, BGC-823, HGC-27, MGC-803, and SGC-7901, were significantly downregulated than those in normal gastric mucosal epithelial cell line GES-1. More importantly, our results indicated that HMlincRNA717 expression levels were correlated with cancer distal metastasis (P = 0.034), venous invasion (P = 0.029), and nervous invasion (P = 0.024). lncRNA-HMlincRNA717 may play crucial roles during cancer occurrence and progression and may be a new potential biomarker of early gastric cancer. |
24961350 |
Lnc2Cancer
|