LncRNA Information
ID	EL0508	Name	FOXC2-AS1	Aliases	ODRUL
Species	Homo sapiens	Chromosome	16	Start site	86565145
End site	86567761	Chain	minus	Exon NO.	2
Assembly	Ensembl Release 89	Class	antisense	NCBI accession	NR_125795
Ensembl	ENSG00000260944	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
osteosarcoma	microarray, qPCR, Western blot, knockdown etc.	cell lines (MG63, SaoS2, U-2OS)	up-regulated	interaction	lncRNA ODRUL was higher in different doxorubicin-resistant OS cell lines and lower in different doxorubicin-sensitive OS cell lines. Moreover, we showed that lncRNA ODRUL was increased in specimens of OS patients with a poor chemoresponse and lung metastasis. We further demonstrated that lncRNA ODRUL inhibition could inhibit OS cell proliferation, migration, and partly reversed doxorubicin resistance in vitro. In addition, we found that the expression of classical drug resistance-related ATP-binding cassette, subfamily B, member 1 (ABCB1) gene was decreased after the lncRNA ODRUL knockdown. Thus, we concluded that lncRNA ODRUL may act as a pro-doxorubicin-resistant molecule through inducing the expression of the classical multidrug resistance-related ABCB1 gene in osteosarcoma cells.	26408180	Lnc2Cancer
osteosarcoma	microarray, qRT-PCR	three sets of doxorubicin-resistant MG63/DXR and their paired parental MG63 cells (fold-change >2.0, P<0.05 and FDR <0.05).	up-regulated	expression	The patients of lower expression of it may survive longer than those of higher expression, which suggest that it may serve as a biomarker to predict the chemoresponse and prognosis of steosarcoma patients.	26463625

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
ABCB1	RNA-DNA	regulation	The expression of classical drug resistance-related ATP-binding cassette, subfamily B, member 1 (ABCB1) gene was decreased after the lncRNA ODRUL knockdown.	26408180