LncRNA Information
ID EL0501 Name Firre Aliases 5830467J12Rik; 6720401G13Rik; AW048145
Species Mus musculus Chromosome X Start site 50555744
End site 50635321 Chain minus Exon NO. 20
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_015505
Ensembl ENSMUSG00000085396 Sequence

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
knockdown mouse embryonic stem cells N/A epigenetics Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus. Knockdown of Firre disrupts perinucleolar targeting and H3K27me3 levels in mouse fibroblasts, demonstrating a role in maintenance of an important epigenetic feature of the inactive X chromosome. 25887447
weighted gene coexpression network analysis mouse embryonic stem cells (ESCs) and neural progenitor cells (NPCs) up-regulated expression Firre, a lncRNA highly enriched in the nucleoplasm and previously reported to mediate chromosomal contacts in ESCs, controls a network of genes related to RNA processing. 26048247