LncRNA Information | ||||||
---|---|---|---|---|---|---|
ID | EL0501 | Name | Firre | Aliases | 5830467J12Rik; 6720401G13Rik; AW048145 | |
Species | Mus musculus | Chromosome | X | Start site | 50555744 | |
End site | 50635321 | Chain | minus | Exon NO. | 20 | |
Assembly | Ensembl Release 89 | Class | processed transcript | NCBI accession | NR_015505 | |
Ensembl | ENSMUSG00000085396 | Sequence |
Function (not disease relevant) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
knockdown | mouse embryonic stem cells | N/A | epigenetics | Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus. Knockdown of Firre disrupts perinucleolar targeting and H3K27me3 levels in mouse fibroblasts, demonstrating a role in maintenance of an important epigenetic feature of the inactive X chromosome. | 25887447 | ||||
weighted gene coexpression network analysis | mouse embryonic stem cells (ESCs) and neural progenitor cells (NPCs) | up-regulated | expression | Firre, a lncRNA highly enriched in the nucleoplasm and previously reported to mediate chromosomal contacts in ESCs, controls a network of genes related to RNA processing. | 26048247 | ||||