LncRNA Information
ID EL0368 Name ELFN1-AS1 Aliases MYCLo-2
Species Homo sapiens Chromosome 7 Start site 1738630
End site 1742291 Chain minus Exon NO. 2
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_120510, NR_120509, NR_120508
Ensembl ENSG00000236081 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) up-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer