LncRNA Information
ID EL0365 Name EGFR-AS1 Aliases N/A
Species Homo sapiens Chromosome 7 Start site 55179750
End site 55188934 Chain minus Exon NO. 2
Assembly Ensembl Release 89 Class antisense NCBI accession NR_047551
Ensembl ENSG00000224057 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hepatocelluar carcinoma microarray, qPCR, Western blot, knockdown, FCA etc. HCC tissue, cell lines of (SMMC-7721, LM-9, Huh-7, HepG2) up-regulated interaction It was verified that EGFR and EGFR-AS1 were relatively upregulated in HCC tissue, and they were significantly related to some clinical characteristics and patient prognosis. Furthermore, EGFR-AS1 was determined to promote HCC development by improving the ability of invasion and proliferation of HCC cells in vitro, and it was also found to affect the cell cycle. Our study identified that EGFR-AS1 may promote HCC genesis and development. EGFR-AS1 may act as a prognostic factor in HCC. 26271667 Lnc2Cancer

Interaction target Level of interaction Type of interaction Description PMID Source
GHR RNA-DNA regulation Impeded expression of GHR decreased the expression of EGFR and EGFR-AS1 in vivo and in vitro. 26271667