LncRNA Information
ID EL0363 Name EFNA3 Aliases EFL2; EPLG3; Ehk1-L; LERK3
Species Homo sapiens Chromosome 1 Start site 155078872
End site 155087538 Chain plus Exon NO. 5
Assembly Ensembl Release 89 Class processed transcript NCBI accession N/A
Ensembl ENSG00000143590 Sequence N/A

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer qPCR, RIP etc. breast cancer tissue up-regulated N/A We demonstrate that sustained expression of both Ephrin-A3 and novel EFNA3 lncRNAs increased the metastatic potential of human breast cancer cells, possibly by increasing the ability of tumor cells to extravasate from the blood vessels into surrounding tissue. In agreement, we found a strong correlation between high EFNA3 expression and shorter metastasis-free survival in breast cancer patients. hypoxia could contribute to metastatic spread of breast cancer via HIF-mediated induction ofEFNA3lncRNAs and subsequent Ephrin-A3 protein accumulation. 25023702 Lnc2Cancer