LncRNA Information
ID EL0358 Name DSCAM-AS1 Aliases M41
Species Homo sapiens Chromosome 21 Start site 40383083
End site 40385358 Chain plus Exon NO. 4
Assembly Ensembl Release 89 Class antisense NCBI accession NR_038898, NR_038896, NR_038900, NR_038899
Ensembl ENSG00000235123 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer cell cultures or fresh tumor biopsies MCF-8 cells in absence of hormones Erα N/A expression Down-regulation of DSCAM-AS1 recapitulated, in part, the effect of silencing ERα, i.e. growth arrest and induction of EMT markers. 26621851
adolescent idiopathic scoliosis N/A N/A N/A mutation Other top associations in our GWAS were with SNPs (rs2222973, C>T) in the DSCAM gene. 21216876 LncRNADisease
breast cancer qPCR, Northern blot, ISH etc. cell lines (MCF-7, T47D, ZR-75-1 etc.) up-regulated expression M41 (DSCAM-AS1) mRNA is expressed at a statistically significantly higher level in human breast cancer specimens than in normal human breast and benign lesions. 12177779 LncRNADisease Lnc2Cancer