| Disease |
| Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| chronic lymphocytic leukemia |
chromatin immunoprecipitation assay, small interfering RNA-mediated repression |
CLL patients, Human Burkitt’s lymphoma cell line Daudi |
down-regulated |
N/A |
The transcription factor BSAP (B-cell-specific activator protein) directly interacts with Dleu2, the host gene containing the miR-15a/16-1 loci, and by negative regulation of the Dleu2 promoter, results in repression of miR-15a/16-1 expression. |
23995789 |
|
| chronic lymphocytic leukemia |
chromatin-immunoprecipitation (ChIP) that are associated with activated transcription; semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing) |
CLL cells |
N/A |
N/A |
the tumor suppressor mechanism at 13q14.3 is a cluster of genes controlled by two lncRNA |
23593011 |
|
| multiple myeloma |
FISH |
myeloma cases |
N/A |
locus |
A cdr of approximately 350 kb was identified at 13q14 with the proximal border approximately 120 kb centromeric from d13s319, encompassing an area rich in expressed sequence tagged sites and containing dleu1, dleu2, and rfp2 genes. |
12461754 |
|
| B-cell chronic lymphocytic leukemia |
N/A |
N/A |
N/A |
mutation |
B-cell chronic lymphocytic leukemia: frequent chromosomal imbalance. |
11072235 |
LncRNADisease
|
| mantle-cell lymphoma |
N/A |
N/A |
N/A |
mutation |
mantle-cell lymphoma: frequent chromosomal imbalance. |
11072235 |
LncRNADisease
|
| B-cell chronic lymphocytic leukemia |
N/A |
N/A |
N/A |
N/A |
No expression of 1b4/leu2 was detectable in b-cll, regardless of the 13q14 status. these results indicate that allelic loss and mutation of a gene within the mdr is an unlikely pathogenetic mechanism for b-cll. |
11264177 |
|
| lymphocytic leukemia |
N/A |
N/A |
N/A |
locus |
Dleu2 is an antisense transcript that encompasses the Kcnrg and Trim13 genes, as well as two microRNA genes, Mirn16-1 and Mirn15a, which have been previously identified in lymphocytic leukemia. |
18562676 |
LncRNADisease
|
| chronic lymphocytic leukemia |
N/A |
N/A |
N/A |
N/A |
DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia |
23551855 |
|
| chronic lymphocytic leukemia |
qPCR etc. |
blood |
differential expression |
locus |
In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region. |
19347735 |
LncRNADisease Lnc2Cancer
|
| chronic lymphocytic leukemia |
qPCR, FISH etc. |
blood |
down-regulated |
mutation |
Frequently deleted in B-cell chronic lymphocytic leukemia. |
11161783 |
LncRNADisease Lnc2Cancer
|
| chronic lymphocytic leukemia |
qPCR, FISH etc. |
blood |
differential expression |
N/A |
Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. |
9395242 |
LncRNADisease Lnc2Cancer
|
| myeloma |
qPCR, Western blot, Northern blot, Luciferase reporter assay etc. |
myeloma tissue, cell lines (HEK293, U2OS etc.) |
down-regulated |
expression |
The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. |
19591824 |
LncRNADisease Lnc2Cancer
|
| chronic lymphocytic leukemia |
qPCR, Western blot, Northern blot, Luciferase reporter assay etc. |
blood, cell lines (HEK293, U2OS etc.) |
down-regulated |
expression |
The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. |
19591824 |
LncRNADisease Lnc2Cancer
|
| lymphoma |
qPCR, Western blot, Northern blot, Luciferase reporter assay etc. |
cell lines (HEK293, U2OS etc.) |
down-regulated |
expression |
The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. |
19591824 |
LncRNADisease Lnc2Cancer
|
| non-small cell lung cancer |
qRT-PCR, Small interfering RNA (siRNA) transfection, Western blotting, ChIP assays |
Pair-matched tumorous and adjacent nontumorous lung tissues from 27 patients, A549 and H1299 |
up-regulated |
N/A |
Histone deacetylases, HDACs inhibitors trichostatin A (TSA) and sodium butyrate upregulated the expression of miR-15a/16-1, among class Ι HDACs subtypes, only knockdown of HDAC3 by specific siRNA increased the hyperacetylation of Dleu2/miR-15a/16-1 promoter region and finally resulted in the upregulation of miR-15a/16-1.overexpression of miR-15a/16-1, which were always deleted or downregulated in lung cancer cells, effectively suppressed cell growth and reduced colony formation |
23867991 |
|
| |