| Disease |
| Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| Autism spectrum disorder |
N/A |
N/A |
N/A |
regulation |
DISC1 is regulated by its lncRNA, DISC6, which may also represent an excellent candidate for susceptibility to these disorders. |
22817756 |
LncRNADisease
|
| schizophrenia |
N/A |
N/A |
N/A |
locus |
DISC2 should be considered a formal candidate gene for susceptibility to psychiatric illness (schizophrenia). |
10814723 |
LncRNADisease
|
| schizophrenia |
N/A |
N/A |
N/A |
mutation |
The Disrupted in Schizophrenia (DISC) locus on human chromosome 1q42 has been strongly implicated by genetic studies as a susceptibility locus for major mental illnesses.DISC2, a putative noncoding transcript partially antisense to DISC1, is not conserved. |
12573262 |
LncRNADisease
|
| affective disorders |
N/A |
N/A |
N/A |
N/A |
DISC2 is a likely susceptibility locus for both schizophrenia and affective disorders. |
15478311 |
LncRNADisease
|
| schizophrenia |
N/A |
N/A |
N/A |
N/A |
DISC2 is a likely susceptibility locus for both schizophrenia and affective disorders. |
15478311 |
LncRNADisease
|
| bipolar disorder |
N/A |
N/A |
N/A |
locus |
The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. |
17912248 |
LncRNADisease
|
| depression |
N/A |
N/A |
N/A |
locus |
The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. |
17912248 |
LncRNADisease
|
| schizophrenia |
N/A |
N/A |
N/A |
locus |
The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. |
17912248 |
LncRNADisease
|
| Autism spectrum disorder |
N/A |
N/A |
N/A |
locus |
The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. |
19606485 |
LncRNADisease
|
| schizophrenia |
N/A |
N/A |
N/A |
locus |
The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. |
20380817 |
LncRNADisease
|
| bipolar disorder |
N/A |
N/A |
N/A |
regulation |
DISC1 is regulated by its lncRNA, DISC4, which may also represent an excellent candidate for susceptibility to these disorders. |
22817756 |
LncRNADisease
|
| major depression |
N/A |
N/A |
N/A |
regulation |
DISC1 is regulated by its lncRNA, DISC5, which may also represent an excellent candidate for susceptibility to these disorders. |
22817756 |
LncRNADisease
|
| schizophrenia |
N/A |
N/A |
N/A |
regulation |
DISC1 is regulated by its lncRNA, DISC3, which may also represent an excellent candidate for susceptibility to these disorders. |
22817756 |
LncRNADisease
|
| Autism spectrum disorder |
N/A |
N/A |
N/A |
regulation |
Genomic context links lncRNAs to disease genes/loci and related pathways |
23791884 |
LncRNADisease
|
| bipolar disorder |
N/A |
N/A |
N/A |
regulation |
Genomic context links lncRNAs to disease genes/loci and related pathways |
23791884 |
LncRNADisease
|
| major depression |
N/A |
N/A |
N/A |
regulation |
Genomic context links lncRNAs to disease genes/loci and related pathways |
23791884 |
LncRNADisease
|
| schizophrenia |
N/A |
N/A |
N/A |
regulation |
Genomic context links lncRNAs to disease genes/loci and related pathways |
23791884 |
LncRNADisease
|
| |