| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0338 | Name | DHRS4-AS1 | Aliases | AS1DHRS4; C14orf167; DHRS4AS1; PRO1488 | |
| Species | Homo sapiens | Chromosome | 14 | Start site | 23938731 | |
| End site | 23988839 | Chain | minus | Exon NO. | 4 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_023922, NR_023923, NR_023924, NR_023921 | |
| Ensembl | ENSG00000215256 | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| gene duplication | N/A | N/A | N/A | AS1DHRS4 not only mediates deacetylation of histone H3 and demethylation of H3K4 in cis for the DHRS4 gene, but also interacts physically in trans with the epigenetic modifiers H3K9- and H3K27-specific histone methyltransferases G9a and EZH2, targeting the promoters of the downstream DHRS4L2 and DHRS4L1 genes to induce local repressive H3K9me2 and H3K27me3 histone modifications. | 22891334 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| H3K9- and H3K27-specific histone methyltransferases G9a and EZH2 | RNA-DNA | regulation | AS1DHRS4 interacts physically in trans with the epigenetic modifiers H3K9- and H3K27-specific histone methyltransferases G9a and EZH2 | 22891334 | |||||