LncRNA Information
ID EL0033 Name Adapt15 Aliases Gadd7
Species Cricetulus griseus Chromosome Unplaced Scaffold Start site 2388364
End site 2390088 Chain N/A Exon NO. 5
Assembly CriGri_1.0 Class N/A NCBI accession NR_045124
Ensembl N/A Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
obesity knockdown mutant Chinese hamster ovary cell line N/A mutation Here we report that gadd7 is induced by lipotoxic stress in a reactive oxygen species (ROS)-dependent fashion and is necessary for both lipid- and general oxidative stress-mediated cell death. Depletion of gadd7 by mutagenesis or short hairpin RNA knockdown significantly reduces lipid and non-lipid induced ROS 19150982
diabetes knockdown mutant Chinese hamster ovary cell line N/A mutation Here we report that gadd7 is induced by lipotoxic stress in a reactive oxygen species (ROS)-dependent fashion and is necessary for both lipid- and general oxidative stress-mediated cell death. Depletion of gadd7 by mutagenesis or short hairpin RNA knockdown significantly reduces lipid and non-lipid induced ROS 19150982
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
methylmeth- anesulfonate and cis-platinum, X-irradiation hamster HA-1 fibroblasts up-regulated expression These rnas may act in concert to protect cells against the damaging effects of oxidative stress. 8638945
RT-PCR, knockdown, MTT assay N/A N/A interaction Gadd7 regulates the G1/S checkpoint in response to UV irradiation. 23103768
UV radiation, overexpression Chinese hamster ovary (CHO) cells up-regulated expression Overexpression of gadd7 led to a decrease in cell growth. interestingly, gadd7 cdna does not contain an appreciable open reading frame and does not appear to encode a protein product, but instead may function at the rna level. 8649973
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
TDP-43 RNA-Protein binding UV-induced gadd7 directly binds to TAR DNA-binding protein (TDP-43) and interferes with the interaction between TDP-43 and cyclin-dependent kinase 6 (Cdk6) mRNA, resulting in Cdk6 mRNA degradation. 23103768
Cdk6 RNA-RNA regulation UV-induced gadd7 directly binds to TAR DNA-binding protein (TDP-43) and interferes with the interaction between TDP-43 and cyclin-dependent kinase 6 (Cdk6) mRNA, resulting in Cdk6 mRNA degradation. 23103768
gadd45 and gadd153 RNA-RNA co-expression Near identical responses were also observed for gadd45 and gadd153 rnas, suggesting coordinate regulation of adapt15, gadd45, and gadd153. 8638945