LncRNA Information
ID EL0329 Name DANCR Aliases AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR
Species Homo sapiens Chromosome 4 Start site 52712404
End site 52720351 Chain plus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_024031
Ensembl ENSG00000226950 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
osteosarcoma Lentivirus-mediated (shRNA) to silence osteosarcoma cell lines U2OS and Saos-2 osteosarcoma cell lines U2OS and Saos-2 up-regulated N/A knockdown of ANCR significantly inhibited the proliferation of U2OS and Saos cells and colony formation of U2OS cells 26986815
prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
bone diseases N/A N/A N/A expression These data suggest that ANCR is an essential mediator of osteoblast differentiation, thus offering a new target for the development of therapeutic agents to treat bone diseases. 23438432 LncRNADisease
postmenopausal osteoporosis N/A N/A N/A N/A DANCR promoted the expression of IL6 and TNF-alpha at both mRNA level and protein level in MNCs. DANCR level was correlated with IL6 and TNF-alpha in postmenopausal women with low BMD 25660720 LncRNADisease
hepatocelluar carcinoma qPCR etc. HCC cell lines up-regulated interaction We found that lncRNA-DANCR is over-expressed in stem-like HCC cells and this can serve as a prognostic biomarker for HCC patients. Experiments showed that DANCR markedly increased stemness features of HCC cells to promote tumorigenesis and intra-/extra-hepatic tumor colonization.Our studies reveal a significance and mechanism of DANCR action in increasing stemness features and offer a potential prognostic marker and a therapeutic target for HCC. 25964079 Lnc2Cancer
colorectal cancer qPCR etc. colorectal cancer tissues and paired adjacent non-tumor tissues up-regulated expression Our results showed that lncRNA DANCR expression was increased in CRC tissues compared with that in adjacent normal tissues (P<0.05). In addition, tumors with high lncRNA DANCR expression was correlated with TNM stage, histologic grade, and lymph node metastasis (P<0.05). Kaplan-Meier analysis showed that patients with high lncRNA DANCR expression had a shorter overall survival (OS) and disease-free survival (DFS) compared with the low lncRNA DANCR expression group (P<0.05). Moreover, in a multivariate Cox model, our results showed that lncRNA DANCR expression was an independent poor prognostic factor for both OS and DFS in CRC. 26617879 Lnc2Cancer

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
knockdown Synovium-derived mesenchymal stem cells (SMSCs) N/A interaction N/A 26514989
microarray, quantitative real-time reverse transcription plus the polymerase chain reaction, overexpression human dental pulp cells down-regulated interaction N/A 26646542

Interaction target Level of interaction Type of interaction Description PMID Source
CTNNB1 RNA-DNA regulation Association of DANCR with CTNNB1 blocked the repressing effect of microRNA (miR)-214, miR-320a, and miR-199a on CTNNB1. 25964079
Sox4 DNA-Protein binding Sox4 could directly bind to the promoter of long noncoding RNA DANCR and increased its expression. Knockdown of DANCR could reverse the stimulative effect of Sox4 on the proliferation and chondrogenesis of SMSCs. 26514989
DSPP and DMP-1, p-GSK-3β and β-catenin RNA-Protein regulation lncRNA DANCR overexpression blocked mineralized nodule formation and the expression of DSPP and DMP-1 in hDPCs after 14 days of odontogenic induction. Importantly, the upregulation of DANCR significantly decreased the expression levels of p-GSK-3β and β-catenin expression indicating that lncRNA DANCR can inhibit the activation of the Wnt/β-catenin signal pathway during the odontoblast-like differentiation of hDPCs. 26646542