| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0327 | Name | DACOR1 | Aliases | LP2570; TCONS_00023265 | |
| Species | Homo sapiens | Chromosome | 15 | Start site | N/A | |
| End site | N/A | Chain | N/A | Exon NO. | N/A | |
| Assembly | N/A | Class | N/A | NCBI accession | N/A | |
| Ensembl | N/A | Sequence | N/A | |||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| colon cancer | RNA-seq, qPCR, ChIRP-seq, Western blot, RIP etc. | colon cancer tissue, cell line (HCT116) | down-regulated | interaction | DACOR1 shows high, tissue-specific expression in the normal colon but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. Induction of DACOR1 in colon cancer cell lines significantly reduced their ability to form colonies in vitro, suggesting a growth suppressor function. Induction of DACOR1 led to the activation of tumor-suppressor pathways and attenuation of cancer-associated metabolic pathways. | 26307088 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| Cystathionine β-synthase | RNA-Protein | regulation | DACOR1 induction resulted in down-regulation of Cystathionine β-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation. | 26307088 | |||||