LncRNA Information
ID EL0305 Name CRNDE Aliases CRNDEP; LINC00180; NCRNA00180; PNAS-108; lincIRX5
Species Homo sapiens Chromosome 16 Start site 54845189
End site 54929189 Chain minus Exon NO. 7
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_034105, NR_110453, NR_110454, NR_034106
Ensembl ENSG00000245694 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
colorectal cancer microarray, qPCR, knockdown etc. cell lines (HCT116, HT29, LS174T etc.) up-regulated N/A In colorectal cancer cells, we demonstrate that treatment with insulin and insulin-like growth factors (IGF) repressed CRNDE nuclear transcripts, including those encompassing gVC-In4. These repressive effects were negated by use of inhibitors against either the PI3K/Akt/mTOR pathway or Raf/MAPK pathway, suggesting CRNDE is a downstream target of both signaling cascades. 24184209 Lnc2Cancer
colorectal cancer qPCR etc. CRC tissue up-regulated expression An uncharacterized gene locus (Chr16:hCG_1815491), now named colorectal neoplasia differentially expressed (gene symbol CRNDE), is activated early in colorectal neoplasia. 22393467 LncRNADisease Lnc2Cancer
glioma qPCR, Western blot, ChIP, Flow cytometry assay etc. glioma tissue, cell lines(U87MG, U251) up-regulated expression Overexpression of specific CRNDE transcript promotes cell growth and migration in vitro while knockdown of CRNDE expression manifests a repressive function during these cellular processes. Mechanistic studies further revealed that histone acetylation in the promoter region might account for the upregulation of CRNDE, and the level of CRNDE expression could be modulated by mammalian Target of Rapamycin (mTOR) signaling in glioma. 25813405 Lnc2Cancer
colorectal cancer quantitative real-time 142 CRC tissues and 142 paired adjacent nontumorous tissues up-regulated N/A upregulation of lncRNA CRNDE-h was significantly correlated with large tumor size 27042112