LncRNA Information
ID EL0290 Name CDR1-AS Aliases CDR1NAT; CDR1as; ciRS-7
Species Homo sapiens Chromosome X Start site N/A
End site N/A Chain N/A Exon NO. N/A
Assembly N/A Class N/A NCBI accession AK094540
Ensembl N/A Sequence

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A mouse brain N/A N/A acts as a miR-7 sponge 23446346
sequence and computationally analysis, knockdown N/A N/A N/A CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. 23446348

Interaction target Level of interaction Type of interaction Description PMID Source
miR-7 RNA-RNA co-expression ciRS-7 contains more than 70 selectively conserved miRNA target sites, and it is highly and widely associated with Argonaute (AGO) proteins in a miR-7-dependent manner. Although the circRNA is completely resistant to miRNA-mediated target destabilization, it strongly suppresses miR-7 activity, resulting in increased levels of miR-7 targets. In the mouse brain, we observe overlapping co-expression of ciRS-7 and miR-7, particularly in neocortical and hippocampal neurons, suggesting a high degree of endogenous interaction. 23446346