LncRNA Information
ID EL0283 Name CCEPR Aliases CCHE1; lncRNA-CCHE1
Species Homo sapiens Chromosome 10 Start site 59173963
End site 59176464 Chain minus Exon NO. 1
Assembly GRCh38.p7 Class N/A NCBI accession NR_131782
Ensembl N/A Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
cervical cancer qPCR, Western blot, knockdown, RNA pull-down assay etc. cervical cancer tissue, cell lines (HeLa, SiHa) up-regulated interaction In this study, we found that cervical carcinoma high-expressed lncRNA 1 (lncRNA-CCHE1) was significantly upregulated in cervical cancer tissues. The higher expression of CCHE1 was significantly correlated with large tumor size, advanced Federation of Gynecology and Obstetrics stage, uterine corpus invasion, and poor survival. CCHE1 plays a pivotal role in cervical cancer cell proliferation via increasing PCNA expression and serves as a potential prognostic biomarker and therapeutic target in human cervical cancer. 25921283 Lnc2Cancer

Interaction target Level of interaction Type of interaction Description PMID Source
PCNA RNA-DNA regulation RNA pull-down assays confirmed that CCHE1 physically associates with proliferating cell nuclear antigen (PCNA) messenger RNA, consequently enhances the expression of PCNA. The expression of CCHE1 and PCNA is significantly correlated in cervical cancer tissues. 25921283