LncRNA Information
ID EL0278 Name CCAT2 Aliases LINC00873; NCCP1
Species Homo sapiens Chromosome 8 Start site 127400399
End site 127402150 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_109834
Ensembl ENSG00000280997 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer microarray, qPCR, knockdown etc. breast cancer tissue, cell lines (SUM149, SUM190, MDA-MB-231, MDA-MB-436 etc.) up-regulated expression CCAT2, a novel long non-coding RNA in breast cancer. 24077681 LncRNADisease Lnc2Cancer
colon cancer qPCR etc. colon cancer tissue up-regulated interaction Our results revealed that CCAT1 was significantly overexpressed in colon cancer tissues when compared with normal tissues, and its increased expression was correlated with patients' clinical stage, lymph nodes metastasis, and survival time after surgery. Moreover, c-Myc could promote CCAT1 transcription by diretcly binding to its promoter region, and upregulation of CCAT1 expression in colon cancer cells promoted cell proliferation and invasion. 25185650 Lnc2Cancer
esophageal squamous cell carcinoma qPCR etc. ESCC tissue, cell lines (KYSE410) up-regulated expression In silico analysis showed that no CpG island is found in the chromosome region of CCAT2, indicating that the expression of CCAT2 is possibly not regulated by DNA methylation.Compared with paired adjacent normal esophageal tissues, CCAT2 was significantly overexpressed in ESCC tissues with an average fold of 7.18. In ESCC cell lines, CCAT2 was mostly upregulated in KYSE410 cell when normalized to normal esophageal epithelium cell line (HEEC) and most CCAT2 transcripts were located in nucleus (>95 %). Statistical analysis showed that CCAT2 expression level was significantly associated with smoking status. 25677908 Lnc2Cancer
esophageal squamous cell carcinoma qPCR etc. ESCC tissue up-regulated expression CCAT2 was upregulated in ESCC tissues, especially in cases with lymph node metastasis (LNM), advanced TNM stages, and MYC amplification. Furthermore, the level of CCAT2 was positively correlated with TNM stages, LNM, and the number of positive lymph nodes. High CCAT2 expression and MYC amplification were significantly associated with TNM stages and LNM. CCAT2 may have great potential prognostic value for assessing postoperative ESCC patients. 25919911 Lnc2Cancer
non-small cell lung cancer qPCR, knockdown etc. NSCLC tissue, cell lines (A549, NCI-H1975, NCI-H358, NCI-H1650, NCI-H1299, SK-MES-1 etc.) up-regulated regulation CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. 24504682 LncRNADisease Lnc2Cancer
gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines (BGC-823, SGC-7901, AGS, MKN-45, HGC-27 etc.) up-regulated expression Expression levels of lncRNA CCAT2 in gastric cancer tissues were significantly higher than those in adjacent non-tumor tissues. By statistical analyses, high lncRNA CCAT2 expression was observed to be closely correlated with higher incidence of lymph node metastasis and distance metastasis. Moreover, patients with high lncRNA CCAT2 expression had shorter overall survival and progression-free survival compared with the low lncRNA CCAT2 group. 25755774 Lnc2Cancer
colorectal cancer qPCR, RIP etc. CRC tissue, cell lines (COLO320DM, HCT116, RKO, HEK293 etc.) up-regulated N/A Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. Our results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation on the SNP-conferred cancer risk. 23796952 Lnc2Cancer
breast cancer qPCR, Western blot, knockdown etc. breast cancer tissue and adjacent normal breast tissue, cell lines (MDA-MB-231, MCF-7) up-regulated interaction We first confirmed the high expression level of CCAT2 in breast cancer tissues and breast cancer cell lines by reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay, and we further analyzed the relationship between CCAT2 expression and clinical prognostic factors. Also, the biological function of CCAT2 was explored and the results showed silencing of CCAT2 could suppress cell growth in vitro and tumor formation in vivo. Finally, our results revealed that the abnormal expression of CCAT2 could influence the Wnt signaling pathway. 26442763 Lnc2Cancer
cervical squamous cell cancer qRT-PCR 123 cervical squamous cell tumor specimens up-regulated expression High expression of lncRNA CCAT2 is related to the prognosis of cervical squamous cell cancer. 26722527
cervical cancer quantitative real-time PCR cervical cancer cell lines up-regulated N/A CCAT2 knockdown inhibited cell proliferation in HeLa, CaSki and SiHa cells 26983975

Interaction target Level of interaction Type of interaction Description PMID Source
c-Myc DNA-TF binding c-Myc could promote CCAT1 transcription by directly binding to its promoter region 25185650
Wnt signaling pathway N/A regulation The abnormal expression of CCAT2 could influence the Wnt signaling pathway. 26442763