LncRNA Information
ID EL0265 Name CADM1 Aliases BL2; IGSF4; IGSF4A; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; sgIGSF; synCAM1
Species Homo sapiens Chromosome 11 Start site 115169218
End site 115504957 Chain minus Exon NO. 16
Assembly Ensembl Release 89 Class processed transcript NCBI accession N/A
Ensembl ENSG00000182985 Sequence N/A

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
clear cell renal cell carcinoma qPCR, knockdown etc. renal cancer tissue, cell lines(786-O, ACHN etc.) down-regulated interaction The results showed that CADM1-AS1 expression was down-regulated in tumor tissues in 64 patients with ccRCC compared with adjacent non-tumor tissues. Furthermore, the expression of CADM1-AS1 was positively correlated with the expression of mRNA CADM1 in ccRCC specimens. Decreased CADM1-AS1 expression was correlated with the progression of AJCC stage and worse survival of ccRCC patients. Also, multivariate analysis identified low CADM1-AS1 expression as an independent prognostic factor for ccRCC.CADM1-AS1 is a new tumor suppressor in ccRCC which regulates cell proliferation, apoptosis and migration via the expression pattern of CADM1-AS1/CADM1 mRNA gene pairs. 25031695 Lnc2Cancer
glioma qPCR, knockdown etc. glioma cancer tissue, cell lines ( U87, U251, SNB-19 etc.) down-regulated expression The data showed that TSLC1-AS1 expression was down-regulated in tumor tissues compared with that in adjacent normal tissues, and negatively associated with the WHO criteria of the tumors. Overexpression of TSLC1-AS1 resulted in up-regulation of TSLC1 and significant inhibition of cell proliferation, migration and invasion in U87 cells, while knockdown of TSLC1-AS1 in SNB-19 cells showed the opposite effetc. The expression of TSLC1-AS1 was also positively correlated with other tumor suppressors NF1, VHL, PIK3R1 and negatively correlated with the oncogene BRAF. 25031725 Lnc2Cancer

Interaction target Level of interaction Type of interaction Description PMID Source
CADM1 mRNA RNA-RNA co-expression CADM1-AS1 expression was positively associated with CADM1 mRNA expression in 786-O cells and ACHN cells. 25031695
TSLC1 RNA-RNA regulation A novel lncRNA, TSLC1-AS1, is the antisense transcript of tumor suppressor TSLC1. 25031725