LncRNA Information
ID EL0235 Name BCAR4 Aliases N/A
Species Homo sapiens Chromosome 16 Start site 11819829
End site 11828845 Chain minus Exon NO. 5
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_131216, NR_131222, NR_024050, NR_131217, NR_024049
Ensembl ENSG00000262117 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer microarray, qPCR, knockdown etc. cell lines (ZR-75-1, MCF7, BCAR4 etc.) differential expression expression BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib. 22892392 LncRNADisease Lnc2Cancer
breast cancer N/A N/A N/A N/A BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase. 25416949 LncRNADisease
breast cancer qPCR etc. cell line (ZR-75-1) up-regulated N/A Breast cancer anti-estrogen resistance 4 (BCAR4), caused OH-TAM resistance and anchorage-independent cell growth in ZR-75-1 cells. 16778085 LncRNADisease Lnc2Cancer
breast cancer qPCR etc. cell line (ZR-75-1) up-regulated expression BCAR4 is expressed in 27% of primary breast tumors. Forced expression of BCAR4 in human ZR-75-1 and MCF7 breast cancer cells resulted in cell proliferation in the absence of estrogen and in the presence of various antiestrogens.BCAR4 may be a good target for treating antiestrogen-resistant breast cancer. 21506106 LncRNADisease Lnc2Cancer
breast cancer qPCR, Western blot etc. cell lines (ZR-75-1, BCAR3, EGFR etc.) up-regulated expression High BCAR4 mRNA levels were associated with poor MFS and overall survival, reflecting tumour aggressiveness. 20859285 LncRNADisease Lnc2Cancer