LncRNA Information
ID EL0215 Name ATXN7L3B Aliases lnc-SCA7
Species Homo sapiens Chromosome 12 Start site 74537827
End site 74545430 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class N/A NCBI accession N/A
Ensembl ENSG00000253719 Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
spinocerebellar ataxia type 7 N/A N/A N/A N/A STAGA is required for the transcription initiation of miR-124, which in turn mediates the post-transcriptional cross-talk between lnc-SCA7, a conserved long noncoding RNA,and ATXN7 mRNA. In SCA7, mutations in ATXN7 disrupt these regulatory interactions and result in a neuron-specific increase in ATXN7 expression. Strikingly, in mice this increase is most prominent in the SCA7 disease-relevant tissues, namely the retina and cerebellum. 25306109 LncRNADisease