LncRNA Information
ID EL1532 Name APELA Aliases ELA, Ende, tdl
Species Homo sapiens Chromosome 4 Start site 164877004
End site 164898965 Chain plus Exon NO. 4
Assembly Ensembl Release 89 Class N/A NCBI accession NM_001297550, XM_017007623
Ensembl ENSG00000248329 Sequence

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
RNA-Seq, Rescue and overexpression, knockdown, In situ hybridization N/A N/A interaction Toddler is annotated as a non-coding RNA in zebrafish (ENSDARG00000094729), mouse [Gm10664; also called Ende], and human (LOC100506013) and is present in two lncRNA catalogs; however, it contains a 58–amino acid ORF with a predicted signal sequence and high conservation in vertebrates, including human. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. 26387754, 25639753, 20153842, 24316148, 24407481

Interaction target Level of interaction Type of interaction Description PMID Source
APJ/Apelin receptors Peptide-Protein regulation Toddler drives internalization of G protein–coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. 26387754, 25639753, 20153842, 24316148, 24407481