LncRNA Information
ID EL1533 Name apela Aliases ELABELA, ela, si:ch211-42i9.4, tdl
Species Danio rerio Chromosome 1 Start site 18975010
End site 18980963 Chain minus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NM_001297547
Ensembl ENSDARG00000094729 Sequence

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
RNA-Seq, Rescue and overexpression, knockdown, In situ hybridization early zebrafish embryogenesis N/A interaction Toddler is annotated as a non-coding RNA in zebrafish (ENSDARG00000094729), mouse [Gm10664; also called Ende], and human (LOC100506013) and is present in two lncRNA catalogs; however, it contains a 58–amino acid ORF with a predicted signal sequence and high conservation in vertebrates, including human. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. 24407481

Interaction target Level of interaction Type of interaction Description PMID Source
APJ/Apelin receptors Peptide-Protein regulation Toddler drives internalization of G protein–coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. 24407481