| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1516 | Name | ZEB2-AS1 | Aliases | ZEB2-AS; ZEB2AS; ZEB2NAT | |
| Species | Homo sapiens | Chromosome | 2 | Start site | 144518097 | |
| End site | 144521477 | Chain | plus | Exon NO. | 4 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_040248 | |
| Ensembl | ENSG00000238057 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| bladder cancer | qPCR etc. | bladder cancer cell lines (T24, 5637 and J82) | up-regulated | interaction | A long non-coding RNA, ZEB2NAT, was demonstrated to be essential for this TGFβ1-dependent process. ZEB2NAT depletion reversed CAF-CM-induced EMT and invasion of cancer cells, as well as reduced the ZEB2 protein level. Consistently, TGFβ1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein levels in human bladder cancer specimens. | 26152796 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| TGFβ1 | RNA-RNA | co-expression | TGFβ1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein levels in human bladder cancer specimens. | 26152796 | |||||