LncRNA Information
ID EL1446 Name VLDLR-AS1 Aliases linc-VLDLR; lincRNA-VLDLR
Species Homo sapiens Chromosome 9 Start site 2422702
End site 2643359 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class antisense NCBI accession NR_015375
Ensembl ENSG00000236404 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hepatocelluar carcinoma qPCR, Western blot, knockdown etc. cell lines (HepG2, Hep3B, PLC/PRF-5, Huh-7) up-regulated N/A lincRNA-VLDLR (linc-VLDLR) was significantly upregulated in malignant hepatocytes. Exposure of HCC cells to diverse anticancer agents such as sorafenib, camptothecin, and doxorubicin increased linc-VLDLR expression in cells as well as within EVs released from these cells. Incubation with EVs reduced chemotherapy-induced cell death and also increased linc-VLDLR expression in recipient cells. RNAi-mediated knockdown of linc-VLDLR decreased cell viability and abrogated cell-cycle progression. 24874432 Lnc2Cancer