LncRNA Information
ID EL1435 Name UFC1 Aliases HSPC155
Species Homo sapiens Chromosome 1 Start site 161152776
End site 161158856 Chain plus Exon NO. 8
Assembly Ensembl Release 89 Class processed transcript NCBI accession N/A
Ensembl ENSG00000143222 Sequence N/A

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hepatocelluar carcinoma microarray, qPCR, in vitro knockdown etc. HCC tissue, cell lines (BEL-7402, SK-Hep1, Huh7, MHCC-97H) up-regulated regulation Levels of the lincRNA-UFC1 were increased in HCC tissues compared with controls, and associated with tumor size, Barcelona Clinic Liver Cancer stage, and patient outcomes. Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effetcs. 25449213 Lnc2Cancer

Interaction target Level of interaction Type of interaction Description PMID Source
microRNA 34a RNA-RNA regulation The lincRNA-UFC1, a target of microRNA 34a, promotes proliferation and reduces apoptosis in HCC cells to promote growth of xenograft tumors in mice. 25449213