LncRNA Information
ID EL1401 Name TUNAR Aliases HI-LNC78; LINC00617; TUNA
Species Homo sapiens Chromosome 14 Start site 95876392
End site 95925571 Chain plus Exon NO. 4
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_132399, NR_132398, NR_038861
Ensembl ENSG00000250366 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer qPCR, Western blot, Luciferase reporter assays, RNA Pull-Down Assay, RPI etc. breast cancer tissues and adjacent nontumor tissues, cell lines (MCF7, T47D, BT474, and MDA-MB-468) up-regulated interaction We found the human ortholog of TUNA, linc00617, was upregulated in breast cancer samples. Linc00617 promoted motility and invasion of breast cancer cells and induced epithelial-mesenchymal-transition (EMT), which was accompanied by generation of stem cell properties. Moreover, knockdown of linc00617 repressed lung metastasis in vivo. We demonstrated that linc00617 upregulated the expression of stemness factor Sox2 in breast cancer cells, which was shown to promote the oncogenic activity of breast cancer cells by stimulating epithelial-to-mesenchymal transition and enhancing the tumor-initiating capacity 26207516 Lnc2Cancer

Interaction target Level of interaction Type of interaction Description PMID Source
Sox2 RNA-DNA regulation Linc00617 functions as an important regulator of EMT and promotes breast cancer progression and metastasis via activating the transcription of Sox2. 26207516